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Article

Influence of the vitamin D plasma level and vitamin D-related genetic polymorphisms on the immune status of patients with type 1 diabetes: a pilot study.

Clinical and experimental immunology - 1 Feb 2013

Rose K, Penna-Martinez M, Klahold E, Kärger D, Shoghi F, Kahles H, Bayer M, Hintermann E, Pfeilschifter J M, Badenhoop K, Ramos-Lopez E, Christen U

Abstract excerpt

Vitamin D (VD) has been implicated in type 1 diabetes (T1D) by genetic and epidemiological studies. Individuals living in regions with low sunlight exposure have an increased T1D risk and VD supplementation reduced the risk in human individuals and mouse models. One possibility of how VD influences the pathogenesis of T1D is its immunomodulatory effect on dendritic cells (DC), which then preferentially activate...

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Identifiers

PMID: 23286944
DOI: 10.1111/cei.12013
PMCID: PMC3573288

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DBP

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