Article
[Aryl hydrocarbon receptor interacting protein gene and familial isolated pituitary adenomas].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae - 1 Dec 2012
Cai Feng, Zhang Yi-dan, Dai Cong-xin, Liu Xiao-hai, Yang Ya-kun, Yao Yong, Wang Ren-zhi
Abstract excerpt
Familial isolated pituitary adenoma (FIPA) is an autosomal dominant disease, characterized by low penetrance, early-onset disease, more invasive tumor growth, as well as somatotroph and lactotroph adenomas in most cases. It has been indicated that the aryl hydrocarbon receptor interacting protein (AIP) gene is a tumor suppressor gene. Many heterozygous mutations have been discovered in AIP in about 20% of FIPA...
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