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Article

Histone deacetylase HDA6 is functionally associated with AS1 in repression of KNOX genes in arabidopsis.

PLoS genetics - 1 Jan 2012

Luo Ming, Yu Chun-Wei, Chen Fang-Fang, Zhao Linmao, Tian Gang, Liu Xuncheng, Cui Yuhai, Yang Jun-Yi, Wu Keqiang

Abstract excerpt

ASYMMETRIC LEAVES 1 (AS1) is a MYB-type transcription repressor that controls leaf development by regulating KNOX gene expression, but the underlying molecular mechanism is still unclear. In this study, we demonstrated that AS1 can interact with the histone deacetylase HDA6 in vitro and in vivo. The KNOX genes were up-regulated and hyperacetylated in the hda6 mutant, axe1-5, indicating that HDA6 may regulate KNOX...

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Identifiers

PMID: 23271976
DOI: 10.1371/journal.pgen.1003114
PMCID: PMC3521718

Genes

MYB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Histone deacetylase HDA6 is functionally associated with AS1 in repression of KNOX genes in arabidopsis.PMID 23271976Read ↗

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Arabidopsis ASYMMETRIC LEAVES2 (AS2): roles in plant morphogenesis, cell division, and pathogenesis.Semantic proximity Read ↗

Transcription factors AS1 and AS2 interact with LHP1 to repress KNOX genes in Arabidopsis.Semantic proximity Read ↗

Expression of the ASYMMETRIC LEAVES2 gene in the adaxial domain of Arabidopsis leaves represses cell proliferation in this domain and is critical for the development of properly expanded leaves.Semantic proximity Read ↗

Asymmetric leaves2 and Elongator, a histone acetyltransferase complex, mediate the establishment of polarity in leaves of Arabidopsis thaliana.Semantic proximity Read ↗

Dual regulation of ETTIN (ARF3) gene expression by AS1-AS2, which maintains the DNA methylation level, is involved in stabilization of leaf adaxial-abaxial partitioning in Arabidopsis.Semantic proximity Read ↗

HDA6 directly interacts with DNA methyltransferase MET1 and maintains transposable element silencing in Arabidopsis.Semantic proximity Read ↗

Blocking histone deacetylation in Arabidopsis induces pleiotropic effects on plant gene regulation and development.Semantic proximity Read ↗

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