A common variant in the peroxisome proliferator-activated receptor-γ coactivator-1α gene is associated with nonalcoholic fatty liver disease in obese children.

doi:10.3945/ajcn.112.046417

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Article

A common variant in the peroxisome proliferator-activated receptor-γ coactivator-1α gene is associated with nonalcoholic fatty liver disease in obese children.

The American journal of clinical nutrition - 1 Feb 2013

Lin Yu-Cheng, Chang Pi-Feng, Chang Mei-Hwei, Ni Yen-Hsuan

Abstract excerpt

BACKGROUND: The single nucleotide polymorphism in the peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α gene (PPARGC1A) was identified to be associated with nonalcoholic fatty liver disease (NAFLD) in adults. The PPARGC1A gene encodes PGC-1α, which regulates cellular energy metabolism. OBJECTIVE: We aimed to test the hypothesis that the PPARGC1A rs8192678 risk A allele would influence the risk of...

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Identifiers

PMID: 23269818
DOI: 10.3945/ajcn.112.046417

Genes

PNPLA3
PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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