Understanding pathogenic single-nucleotide polymorphisms in multidomain proteins--studies of isolated domains are not enough.

Abstract excerpt

Studying the effects of pathogenic mutations is more complex in multidomain proteins when compared with single domains: mutations occurring at domain boundaries may have a large effect on a neighbouring domain that will not be detected in a single-domain system. To demonstrate this, we present a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Kinetics
• Share to Point Mutation
• Share to Protein Interaction Domains and Motifs