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Article

Mevalonate kinase genotype in children with recurrent fevers and high serum IgD level.

Rheumatology international - 1 Dec 2013

Stabile Achille, Compagnone Adele, Napodano Salvatore, Raffaele Carmela Gerarda Luana, Patti Maria, Rigante Donato

Abstract excerpt

In selected cases, childhood's recurrent fevers of unknown origin can be referred to systemic autoinflammatory diseases as mevalonate kinase deficiency (MKD), caused by mutations in the mevalonate kinase gene (MVK), previously named "hyper-IgD syndrome" due to its characteristic increase in serum IgD level. There is no clear evidence for studying MVK genotype in these patients. From a cohort of 305 children...

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Source

Identifiers

PMID: 23239036
DOI: 10.1007/s00296-012-2577-z

Genes

MVK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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