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Article

Instability of mRNA expression signatures of drug transporters in chronic myeloid leukemia patients resistant to imatinib.

Oncology reports - 1 Feb 2013

Gromicho Marta, Magalhães Marta, Torres Fátima, Dinis Joana, Fernandes Alexandra R, Rendeiro Paula, Tavares Purificação, Laires António, Rueff José, Sebastião Rodrigues António

Abstract excerpt

Despite the success of imatinib mesylate (IM) in the treatment of chronic myeloid leukemia (CML), approximately 30% of patients are resistant to therapy, mostly due to unknown causes. To profile the expression signatures of drug transporters throughout IM therapy and correlate them with resistanc...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to Benzamides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fusion Proteins, bcr-abl

Share to Imatinib Mesylate

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Multidrug Resistance-Associated Proteins

Share to Organic Anion Transporters

Share to Organic Cation Transport Proteins

Source

Identifiers

PMID: 23229016
DOI: 10.3892/or.2012.2153

Genes

ABCB1
ABL1
BCR
ABCC1
ABCG2
MVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23229016-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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