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Article

Pigment-dispersing factor is involved in age-dependent rhythm changes in Drosophila melanogaster.

Journal of biological rhythms - 1 Dec 2012

Umezaki Yujiro, Yoshii Taishi, Kawaguchi Tomoaki, Helfrich-Förster Charlotte, Tomioka Kenji

Abstract excerpt

Most animals show rest/activity rhythms that are regulated by an endogenous timing mechanism, the so-called circadian system. The rhythm becomes weaker with age, but the mechanism underlying the age-associated rhythm change remains to be elucidated. Here we employed Drosophila melanogaster as a model organism to study the aging effects on the rhythm. We first investigated activity rhythms under light-dark (LD)...

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PMID: 23223368
DOI: 10.1177/0748730412462206

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PDF
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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