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Article

MicroRNAs 221 and 222 regulate the undifferentiated state in mammalian male germ cells

5 Dec 2012

Abstract excerpt

Continuity of cycling cell lineages relies on the activities of undifferentiated stem cell-containing subpopulations. Transition to a differentiating state must occur periodically in a fraction of the population to supply mature cells, coincident with maintenance of the undifferentiated state in others to sustain a foundational stem cell pool. At present, molecular mechanisms regulating these activities are...

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PMID: 23221369
DOI: 10.1242/dev.087403

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