Article
Molecular Profiling of Prostatic Acinar Morphogenesis Identifies PDCD4 and KLF6 as Tissue Architecture–Specific Prognostic Markers in Prostate Cancer
4 Dec 2012
Abstract excerpt
Histopathological classification of human prostate cancer (PCA) relies on the morphological assessment of tissue specimens but has limited prognostic value. To address this deficiency, we performed comparative transcriptome analysis of human prostatic acini generated in a three-dimensional basement membrane that recapitulates the differentiated morphological characteristics and gene expression profile of a human...