Article
A high resolution genome-wide scan for significant selective sweeps: an application to pooled sequence data in laying chickens.
PloS one - 1 Jan 2012
Qanbari Saber, Strom Tim M, Haberer Georg, Weigend Steffen, Gheyas Almas A, Turner Frances, Burt David W, Preisinger Rudolf, Gianola Daniel, Simianer Henner
Abstract excerpt
In most studies aimed at localizing footprints of past selection, outliers at tails of the empirical distribution of a given test statistic are assumed to reflect locus-specific selective forces. Significance cutoffs are subjectively determined, rather than being related to a clear set of hypotheses. Here, we define an empirical p-value for the summary statistic by means of a permutation method that uses the...
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