Article
Familial intracranial aneurysms: is anatomic vulnerability heritable?
Stroke - 1 Jan 2013
Mackey Jason, Brown Robert D, Moomaw Charles J, Hornung Richard, Sauerbeck Laura, Woo Daniel, Foroud Tatiana, Gandhi Dheeraj, Kleindorfer Dawn, Flaherty Matthew L, Meissner Irene, Anderson Craig, Rouleau Guy, Connolly E Sander, Deka Ranjan, Koller Daniel L, Abruzzo Todd, Huston John, Broderick Joseph P
Abstract excerpt
BACKGROUND AND PURPOSE: Previous studies have suggested that family members with intracranial aneurysms (IAs) often harbor IAs in similar anatomic locations. IA location is important because of its association with rupture. We tested the hypothesis that anatomic susceptibility to IA location exists using a family-based IA study. METHODS: We identified all affected probands and first-degree relatives (FDRs) with a...
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