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Article

Binding sensitivity of adefovir to the polymerase from different genotypes of HBV: molecular modeling, docking and dynamics simulation studies.

Acta pharmacologica Sinica - 1 Feb 2013

Li Jing, Du Yun, Liu Xian, Shen Qian-cheng, Huang Ai-long, Zheng Ming-yue, Luo Xiao-min, Jiang Hua-liang

Abstract excerpt

AIM: To investigate the molecular mechanisms underlying the influence of DNA polymerase from different genotypes of hepatitis B virus (HBV) on the binding affinity of adefovir (ADV). METHODS: Computational approaches, including homology modeling, docking, MD simulation and MM/PBSA free energy ana...

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Identifiers

PMID: 23202802
DOI: 10.1038/aps.2012.146
PMCID: PMC4011611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23202802-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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