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Article

Histopathological features of biparental complete hydatidiform moles in women with NLRP7 mutations.

Placenta - 1 Jan 2013

Sebire N J, Savage P M, Seckl M J, Fisher R A

Abstract excerpt

OBJECTIVES: Molar pregnancies, characterized by hydropic change and trophoblast hyperplasia of chorionic villi, are usually sporadic. Second and third molar pregnancies can occur by chance but may be associated with a rare autosomal recessive condition, familial recurrent hydatidiform mole (FRHM). This condition, in which affected women have a predisposition to complete hydatidiform moles (CHM), is not usually...

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Source

Identifiers

PMID: 23201303
DOI: 10.1016/j.placenta.2012.11.005

Genes

CHM
NLRP7

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histopathological features of biparental complete hydatidiform moles in women with NLRP7 mutations.PMID 23201303Read ↗

Mutations in NLRP7 are associated with diploid biparental hydatidiform moles, but not androgenetic complete moles.Semantic proximity Read ↗

Comprehensive genotype-phenotype correlations between NLRP7 mutations and the balance between embryonic tissue differentiation and trophoblastic proliferation.Semantic proximity Read ↗

Hydatidiform Moles: Genetic Basis and Precision Diagnosis.Semantic proximity Read ↗

A novel NLRP7 protein-truncating mutation associated with discordant and divergent p57 immunostaining in diploid biparental and triploid digynic moles.Semantic proximity Read ↗

Recurrent pregnancy loss in a woman with NLRP7 mutation: not all molar pregnancies can be easily classified as either "partial" or "complete" hydatidiform moles.Semantic proximity Read ↗

The genetics of hydatidiform moles: new lights on an ancient disease.Semantic proximity Read ↗

Androgenetic/Biparental Mosaic/Chimeric Conceptions With a Molar Component: A Diagnostic and Clinical Challenge.Semantic proximity Read ↗

The genetics of recurrent hydatidiform moles: new insights and lessons from a comprehensive analysis of 113 patients.Semantic proximity Read ↗

Identification of 13 novel NLRP7 mutations in 20 families with recurrent hydatidiform mole; missense mutations cluster in the leucine-rich region.Semantic proximity Read ↗

No evidence for mutations in NLRP7 and KHDC3L in women with androgenetic hydatidiform moles.Semantic proximity Read ↗

NLRP7 mutations in women with diploid androgenetic and triploid moles: a proposed mechanism for mole formation.Semantic proximity Read ↗

Mutations in NLRP7 and KHDC3L confer a complete hydatidiform mole phenotype on digynic triploid conceptions.Semantic proximity Read ↗

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