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Article

Association of human mannose receptor in sexual transmission of human immunodeficiency virus in serodiscordant couples.

AIDS research and human retroviruses - 1 Jan 2013

Jadhav Shivaji K, Velhal Shilpa M, Deshpande Alaka, Bandivdekar Atmaram H

Abstract excerpt

HIV binds specifically to the human mannose receptor (hMR) on vaginal epithelial cells that are devoid of a conventional CD4 receptor. HIV binding to hMR on vaginal epithelial cells induces the production of matrix metalloproteinase 9 (MMP9) leading to degradation of the extracellular matrix, which may increase the risk of HIV entry into vaginal epithelial cells and further transmission into distal cells....

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Topics

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Share to Fluorescent Antibody Technique
Share to Lectins, C-Type

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

Share to Mannose-Binding Lectins

Share to Mannose Receptor

Share to Receptors, CCR5

Share to Receptors, Cell Surface

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Source

Open in PubMed Open full text

Identifiers

PMID: 23148569
DOI: 10.1089/aid.2012.0101
PMCID: PMC3537322

Genes

CCR5
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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