Article
Inhibition of pre-mRNA splicing by a synthetic Blom7α-interacting small RNA.
PloS one - 1 Jan 2012
Löscher Marlies, Schosserer Markus, Dausse Eric, Lee Kiseok, Ajuh Paul, Grillari-Voglauer Regina, Lamond Angus I, Toulmé Jean-Jacques, Grillari Johannes
Abstract excerpt
Originally the novel protein Blom7α was identified as novel pre-mRNA splicing factor that interacts with SNEV(Prp19/Pso4), an essential protein involved in extension of human endothelial cell life span, DNA damage repair, the ubiquitin-proteasome system, and pre-mRNA splicing. Blom7α belongs to the heteronuclear ribonucleoprotein K homology (KH) protein family, displaying 2 KH domains, a well conserved and...
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