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Article

Inverse Correlation of miRNA and Cell Cycle-Associated Genes Suggests Influence of miRNA on Benign Thyroid Nodule Tumorigenesis

9 Nov 2012

Abstract excerpt

CONTEXT: The molecular etiology of cold and benign thyroid nodules (CBTNs) is largely unknown. Increased thyroid epithelial cell proliferation is a hallmark of CBTNs. MicroRNAs (miRNAs) are prominent regulators of cell proliferation. OBJECTIVE: Our objective was to assess the influence of miRNAs on the increased proliferation and thus the molecular etiology of CBTNs. DESIGN: By using microarrays, we defined the...

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PMID: 23144465
DOI: 10.1210/jc.2012-2564

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