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Article

Developmental disorders and altered gene expression in the tropical clawed frog (Silurana tropicalis) exposed to 17α-ethinylestradiol.

Journal of applied toxicology : JAT - 1 Sept 2013

Hirakawa Ikumi, Miyagawa Shinichi, Mitsui Naoko, Miyahara Maki, Onishi Yuta, Kagami Yoshihiro, Kusano Teruhiko, Takeuchi Takashi, Ohta Yasuhiko, Iguchi Taisen

Abstract excerpt

Several endocrine-disrupting chemicals with estrogenic activity can affect sexual development and reproduction in aquatic wildlife. The occurrence of oocytes in the testis (testis-ova) is one reproductive disorder and can be used as a valid endpoint when studying disruptive effects of estrogenic chemicals. To elucidate the molecular basis of testis-ova induction, we conducted gene expression analysis in the...

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PMID: 23129252
DOI: 10.1002/jat.2836

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