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Article

Effects of 17α-ethynylestradiol on sexual differentiation and development of the African clawed frog (Xenopus laevis).

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP - 1 Nov 2012

Tompsett Amber R, Wiseman Steve, Higley Eric, Pryce Sara, Chang Hong, Giesy John P, Hecker Markus

Abstract excerpt

Several studies have shown that exposure of amphibians, including the African clawed frog (Xenopus laevis), to potent estrogens at critical times during development results in feminization and/or demasculinization. However, genotyping of X. laevis has only recently become possible, so studies performed in the past were rarely able to make explicit linkages between genetic and phenotypic sex. Therefore, to further...

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PMID: 22692001
DOI: 10.1016/j.cbpc.2012.06.002

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