Article
Amino acid signatures in the Ovar-DRB1 peptide-binding pockets are associated with Ovine Pulmonary Adenocarcinoma susceptibility/resistance.
Biochemical and biophysical research communications - 30 Nov 2012
Larruskain Amaia, Minguijón Esmeralda, Garcia-Etxebarria Koldo, Arostegui Inmaculada, Moreno Bernardino, Juste Ramón A, Jugo Begoña M
Abstract excerpt
Potential relationships between amino acid motifs of various alleles of the ovine major histocompatibility complex DR (Ovar-DR) molecule and occurrence of clinical OPA caused by JSRV were investigated in a case-control study. Latxa sheep (n=132) screened for presence/absence of pulmonary OPA lesions were typed for their Ovar-DRB1 2nd exon alleles by PCR and sequence-based typing (PCR-SBT). The polymorphic amino...
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