Article
Resequencing of VAX1 in patients with nonsyndromic cleft lip with or without cleft palate.
Birth defects research. Part A, Clinical and molecular teratology - 1 Nov 2012
Nasser Entessar, Mangold Elisabeth, Tradowsky Daniela C, Fier Heide, Becker Jessica, Boehmer Anne C, Herberz Ruth, Fricker Nadine, Barth Sandra, Wahle Philipp, Nowak Stefanie, Reutter Heiko, Reich Rudolf H, Lauster Carola, Braumann Bert, Kreusch Thomas, Hemprich Alexander, Pötzsch Bernd, Hoffmann Per, Kramer Franz-Josef, Knapp Michael, Lange Christoph, Nöthen Markus M, Ludwig Kerstin U
Abstract excerpt
BACKGROUND: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common of all congenital anomalies, and has a multifactorial etiology involving both environmental and genetic factors. Recent genome-wide association studies (GWAS) identified strong association between a locus on chromosome 10q25.3 and NSCL/P in European samples. One gene at 10q25.3, the ventral anterior homeobox 1...
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