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Article

Identification of a dopamine pathway that regulates sleep and arousal in Drosophila.

Nature neuroscience - 1 Nov 2012

Ueno Taro, Tomita Jun, Tanimoto Hiromu, Endo Keita, Ito Kei, Kume Shoen, Kume Kazuhiko

Abstract excerpt

Sleep is required to maintain physiological functions, including memory, and is regulated by monoamines across species. Enhancement of dopamine signals by a mutation in the dopamine transporter (DAT) decreases sleep, but the underlying dopamine circuit responsible for this remains unknown. We found that the D1 dopamine receptor (DA1) in the dorsal fan-shaped body (dFSB) mediates the arousal effect of dopamine in...

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PMID: 23064381
DOI: 10.1038/nn.3238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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