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Article

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.

PLoS genetics - 1 Jan 2012

Lo Jennifer C Y, Jamsai Duangporn, O'Connor Anne E, Borg Claire, Clark Brett J, Whisstock James C, Field Mark C, Adams Vicki, Ishikawa Tomomoto, Aitken R John, Whittle Belinda, Goodnow Christopher C, Ormandy Christopher J, O'Bryan Moira K

Abstract excerpt

A significant percentage of young men are infertile and, for the majority, the underlying cause remains unknown. Male infertility is, however, frequently associated with defective sperm motility, wherein the sperm tail is a modified flagella/cilia. Conversely, a greater understanding of essential mechanisms involved in tail formation may offer contraceptive opportunities, or more broadly, therapeutic strategies...

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Source

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Identifiers

PMID: 23055941
DOI: 10.1371/journal.pgen.1002969
PMCID: PMC3464206

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.PMID 23055941Read ↗

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