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Article

Catechol-O-methyltransferase genotype modifies executive functioning and prefrontal functional connectivity in women with anorexia nervosa.

Journal of psychiatry & neuroscience : JPN - 1 Jul 2013

Favaro Angela, Clementi Maurizio, Manara Renzo, Bosello Romina, Forzan Monica, Bruson Alice, Tenconi Elena, Degortes Daniela, Titton Francesca, Di Salle Francesco, Santonastaso Paolo

Abstract excerpt

BACKGROUND: Anorexia nervosa is characterized by high levels of perseveration and inflexibility, which interfere with successful treatments. Dopamine (DA) signalling seems to play a key role in modulating the prefrontal cortex, since both DA deficiency and excess nega tively influence the efficiency of cognitive functions. The present study explores the effect of a functional polymorphism (Val158Met) in the...

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Source

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Identifiers

PMID: 23046831
DOI: 10.1503/jpn.120068
PMCID: PMC3692721

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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