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Article

Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis.

Journal of bacteriology - 1 Dec 2012

Brautigam Chad A, Deka Ranjit K, Ouyang Zhiming, Machius Mischa, Knutsen Gregory, Tomchick Diana R, Norgard Michael V

Abstract excerpt

Metal ion homeostasis is a critical function of many integral and peripheral membrane proteins. The genome of the etiologic agent of syphilis, Treponema pallidum, is compact and devoid of many metabolic enzyme genes. Nevertheless, it harbors genes coding for homologs of several enzymes that typically require either iron or zinc. The product of the tp0971 gene of T. pallidum, designated Tp34, is a periplasmic...

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Identifiers

PMID: 23042995
DOI: 10.1128/JB.01494-12
PMCID: PMC3510569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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