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Article

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.

Nature genetics - 1 Nov 2012

Hirota Tomomitsu, Takahashi Atsushi, Kubo Michiaki, Tsunoda Tatsuhiko, Tomita Kaori, Sakashita Masafumi, Yamada Takechiyo, Fujieda Shigeharu, Tanaka Shota, Doi Satoru, Miyatake Akihiko, Enomoto Tadao, Nishiyama Chiharu, Nakano Nobuhiro, Maeda Keiko, Okumura Ko, Ogawa Hideoki, Ikeda Shigaku, Noguchi Emiko, Sakamoto Tohru, Hizawa Nobuyuki, Ebe Koji, Saeki Hidehisa, Sasaki Takashi, Ebihara Tamotsu, Amagai Masayuki, Takeuchi Satoshi, Furue Masutaka, Nakamura Yusuke, Tamari Mayumi

Abstract excerpt

Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P(combined) = 8.36 × 10(-18)), the...

Read the complete abstract on PubMed

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Source

Identifiers

PMID: 23042114
DOI: 10.1038/ng.2438

Genes

ACTL9
CARD11
CCDC80
CYP24A1
FLG
GLB1
IL13
IL18R1
IL18RAP
IL1RL1
KIF3A
NLRP10
OR10A3
OVOL1
PFDN4
SLC25A46
TMEM232
TNFRSF6B
ZGPAT
ZNF365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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