Article
Effect of sample stratification on dairy GWAS results.
BMC genomics - 6 Oct 2012
Ma Li, Wiggans George R, Wang Shengwen, Sonstegard Tad S, Yang Jing, Crooker Brian A, Cole John B, Van Tassell Curtis P, Lawlor Thomas J, Da Yang
Abstract excerpt
BACKGROUND: Artificial insemination and genetic selection are major factors contributing to population stratification in dairy cattle. In this study, we analyzed the effect of sample stratification and the effect of stratification correction on results of a dairy genome-wide association study (GWAS). Three methods for stratification correction were used: the efficient mixed-model association expedited (EMMAX)...
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