Article
Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.
The Journal of biological chemistry - 23 Nov 2012
Suntharalingam Amirthaa, Abisambra Jose F, O'Leary John C, Koren John, Zhang Bo, Joe Myung Kuk, Blair Laura J, Hill Shannon E, Jinwal Umesh K, Cockman Matthew, Duerfeldt Adam S, Tomarev Stanislav, Blagg Brian S J, Lieberman Raquel L, Dickey Chad A
Abstract excerpt
BACKGROUND: Mutant myocilin accumulates in the endoplasmic reticulum for unknown reasons. RESULTS: Glucose-regulated protein (Grp) 94 depletion reduces mutant myocilin by engaging autophagy. CONCLUSION: Grp94 triages mutant myocilin through ER-associated degradation, subverting autophagy. SIGNIFICANCE: Treating glaucoma could be possible by inhibiting Grp94 and reducing its novel client, mutant myocilin....
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