Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.

doi:10.1371/journal.pone.0046179

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Article

Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.

PloS one - 1 Jan 2012

García-González María Asunción, Nicolás-Pérez David, Lanas Angel, Bujanda Luis, Carrera Patricia, Benito Rafael, Strunk Mark, Sopeña Federico, Santolaria Santos, Piazuelo Elena, Jiménez Pilar, Campo Rafael, Espinel Jesús, Manzano Marisa, Geijo Fernando, Pellisé María, González-Huix Ferrán, Espinós Jorge, Zaballa Manuel, Titó Llúcia, Barranco Luis, Pazo Roberto, Quintero Enrique

Abstract excerpt

BACKGROUND: Genetic factors influencing the prognosis of gastric adenocarcinoma (GAC) are not well known. Given the relevance of cytokines and other pro-inflammatory mediators in cancer progression and invasiveness, we aimed to assess the prognostic role of several functional cytokine and cyclooxygenase gene polymorphisms in patients with GAC. METHODOLOGY: Genomic DNA from 380 Spanish Caucasian patients with...

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Identifiers

PMID: 23029430
DOI: 10.1371/journal.pone.0046179
PMCID: PMC3460851

Genes

LTA
PTGS1
PTGS2
TGFB1

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