Article
"Seed-Milarity" confers to hsa-miR-210 and hsa-miR-147b similar functional activity.
PloS one - 1 Jan 2012
Bertero Thomas, Grosso Sébastien, Robbe-Sermesant Karine, Lebrigand Kevin, Hénaoui Imene-Sarah, Puisségur Marie-Pierre, Fourre Sandra, Zaragosi Laure-Emmanuelle, Mazure Nathalie M, Ponzio Gilles, Cardinaud Bruno, Barbry Pascal, Rezzonico Roger, Mari Bernard
Abstract excerpt
Specificity of interaction between a microRNA (miRNA) and its targets crucially depends on the seed region located in its 5'-end. It is often implicitly considered that two miRNAs sharing the same biological activity should display similarity beyond the strict six nucleotide region that forms the seed, in order to form specific complexes with the same mRNA targets. We have found that expression of hsa-miR-147b...
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