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Article

A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among related species.

Cell reports - 25 Oct 2012

Hiller Michael, Schaar Bruce T, Indjeian Vahan B, Kingsley David M, Hagey Lee R, Bejerano Gill

Abstract excerpt

Genotype-phenotype mapping is hampered by countless genomic changes between species. We introduce a computational "forward genomics" strategy that-given only an independently lost phenotype and whole genomes-matches genomic and phenotypic loss patterns to associate specific genomic regions with this phenotype. We conducted genome-wide screens for two metabolic phenotypes. First, our approach correctly matches the...

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Identifiers

PMID: 23022484
DOI: 10.1016/j.celrep.2012.08.032
PMCID: PMC3572205

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ABCB4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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