Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drug-induced QT-interval prolongation and recurrent torsade de pointes in a child with heterotaxy syndrome and KCNE1 D85N polymorphism.

Journal of electrocardiology - 1 Jan 2000

Lin Lisheng, Horigome Hitoshi, Nishigami Naoko, Ohno Seiko, Horie Minoru, Sumazaki Ryo

Abstract excerpt

We present a child case of heterotaxy syndrome (asplenia syndrome) after Fontan procedure that showed extreme prolongation of QT interval and torsade de pointes (TdP) after administration of sodium channel blockers for paroxysmal atrial tachycardia. Despite low serum concentration of the drugs, QT prolongation persisted and TdP attacks with unconsciousness recurred, possibly in association with junctional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Long QT Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Potassium Channels, Voltage-Gated

Share to Secondary Prevention

Share to Sodium Channel Blockers

Share to Torsades de Pointes

Source

Identifiers

PMID: 22999324
DOI: 10.1016/j.jelectrocard.2012.07.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drug-induced QT-interval prolongation and recurrent torsade de pointes in a child with heterotaxy syndrome and KCNE1 D85N polymorphism.PMID 22999324Read ↗

Acquired long QT syndrome and torsade de pointes.Semantic proximity Read ↗

Torsades de Pointes electrical storm in children with KCNH2 mutations.Semantic proximity Read ↗

Congenital long QT syndrome: severe torsades de pointes provoked by epinephrine in a digenic mutation carrier.Semantic proximity Read ↗

[Novel mutation in long QT syndrome in a patient with prior diagnosis of epilepsy].Semantic proximity Read ↗

Drug-induced torsades de pointes: the evolving role of pharmacogenetics.Semantic proximity Read ↗

A delayed diagnosis of catecholaminergic polymorphic ventricular tachycardia with a mutant of RYR2 at c.7580T>G for 6 years in a 9-year-old child.Semantic proximity Read ↗

Sudden cardiac arrest during anesthesia in a 30-month-old boy with syndactyly: a case of genetically proven Timothy syndrome.Semantic proximity Read ↗

Torsades de pointes during complete atrioventricular block: Genetic factors and electrocardiogram correlates.Semantic proximity Read ↗

Catecholaminergic Polymorphic Ventricular Tachycardia.Semantic proximity Read ↗

Drug-induced proarrhythmia: risk factors and electrophysiological mechanisms.Semantic proximity Read ↗

Drug-induced arrhythmia: pharmacogenomic prescribing?Semantic proximity Read ↗

Long QT syndrome due to a novel mutation in SCN5A: treatment with ICD placement at 1 month and left cardiac sympathetic denervation at 3 months of age.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.