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Ribosomal DNA Integrating rAAV-rDNA Vectors Allow for Stable Transgene Expression

18 Sept 2012

Abstract excerpt

Although recombinant adeno-associated virus (rAAV) vectors are proving to be efficacious in clinical trials, the episomal character of the delivered transgene restricts their effectiveness to use in quiescent tissues, and may not provide lifelong expression. In contrast, integrating vectors enhance the risk of insertional mutagenesis. In an attempt to overcome both of these limitations, we created new rAAV-rDNA...

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PMID: 22990671
DOI: 10.1038/mt.2012.164

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