Level of cdk5 expression predicts the survival of relapsed multiple myeloma patients

Abstract excerpt

Cyclin-dependent kinase 5 (cdk5) is a small serine/threonine kinase that was identified based on its structural similarity to cdk1 and cdk2, key regulators of mammalian cell cycle progression.1 However, cdk5 is unique in that it is activated by the non-conventional cyclin, p35 or p39, which are abundant in postmitotic neurons.1 Indeed, cdk5 activity has been associated with neuronal functions, such as...

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