Article
Human rotavirus vaccine Rotarix™ provides protection against diverse circulating rotavirus strains in African infants: a randomized controlled trial.
BMC infectious diseases - 13 Sept 2012
Steele Andrew Duncan, Neuzil Kathleen M, Cunliffe Nigel A, Madhi Shabir A, Bos Pieter, Ngwira Bagrey, Witte Desiree, Todd Stacy, Louw Cheryl, Kirsten Mari, Aspinall Sanet, Van Doorn Leen Jan, Bouckenooghe Alain, Suryakiran Pemmaraju V, Han Htay Htay
Abstract excerpt
BACKGROUND: Rotaviruses are the most important cause of severe acute gastroenteritis worldwide in children <5 years of age. The human, G1P[8] rotavirus vaccine Rotarix™ significantly reduced severe rotavirus gastroenteritis episodes in a Phase III clinical trial conducted in infants in South Africa and Malawi. This paper examines rotavirus vaccine efficacy in preventing severe rotavirus gastroenteritis, during...
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