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Article

Combination training in aging individuals modifies functional connectivity and cognition, and is potentially affected by dopamine-related genes.

PloS one - 1 Jan 2012

Pieramico Valentina, Esposito Roberto, Sensi Francesca, Cilli Franco, Mantini Dante, Mattei Peter A, Frazzini Valerio, Ciavardelli Domenico, Gatta Valentina, Ferretti Antonio, Romani Gian Luca, Sensi Stefano L

Abstract excerpt

BACKGROUND: Aging is a major co-risk factor in many neurodegenerative diseases. Cognitive enrichment positively affects the structural plasticity of the aging brain. In this study, we evaluated effects of a set of structured multimodal activities (Combination Training; CT) on cognitive performances, functional connectivity, and cortical thickness of a group of healthy elderly individuals. CT lasted six months....

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Identifiers

PMID: 22937122
DOI: 10.1371/journal.pone.0043901
PMCID: PMC3429431

Genes

COMT
DRD3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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