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Article

Neuromodulatory state and sex specify alternative behaviors through antagonistic synaptic pathways in C. elegans.

Neuron - 23 Aug 2012

Jang Heeun, Kim Kyuhyung, Neal Scott J, Macosko Evan, Kim Dongshin, Butcher Rebecca A, Zeiger Danna M, Bargmann Cornelia I, Sengupta Piali

Abstract excerpt

Pheromone responses are highly context dependent. For example, the C. elegans pheromone ascaroside C9 (ascr#3) is repulsive to wild-type hermaphrodites, attractive to wild-type males, and usually neutral to "social" hermaphrodites with reduced activity of the npr-1 neuropeptide receptor gene. We show here that these distinct behavioral responses arise from overlapping push-pull circuits driven by two classes of...

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Identifiers

PMID: 22920251
DOI: 10.1016/j.neuron.2012.06.034
PMCID: PMC3462069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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