Article
The ovarian response to standard gonadotrophin stimulation depends on FSHR, SHBG and CYP19 gene synergism.
Journal of assisted reproduction and genetics - 1 Nov 2012
Lazaros Leandros A, Hatzi Elissavet G, Pamporaki Christina E, Sakaloglou Prodromos I, Xita Nectaria V, Markoula Sophia I, Stefos Theodoros I, Zikopoulos Konstantinos A, Georgiou Ioannis A
Abstract excerpt
PURPOSE: Follicle stimulating hormone, sex hormone-binding globulin and cytochrome P450 aromatase play crucial roles in the regulation of mammalian reproduction. The synergistic effect of FSHR 307(T/A)/FSHR 680(N/S), SHBG(TAAAA) ( n ) and CYP19(TTTA) ( n ) genotypes on ovarian response to standard...
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