Article
Differential gene expression in granulosa cells from polycystic ovary syndrome patients with and without insulin resistance: identification of susceptibility gene sets through network analysis.
The Journal of clinical endocrinology and metabolism - 1 Oct 2012
Kaur Surleen, Archer Kellie J, Devi M Gouri, Kriplani Alka, Strauss Jerome F, Singh Rita
Abstract excerpt
CONTEXT: Polycystic ovary syndrome (PCOS) is a heterogeneous, genetically complex, endocrine disorder of uncertain etiology in women. OBJECTIVE: Our aim was to compare the gene expression profiles in stimulated granulosa cells of PCOS women with and without insulin resistance vs. matched controls. RESEARCH DESIGN AND METHODS: This study included 12 normal ovulatory women (controls), 12 women with PCOS without...
Topics
- Cardiovascular Diseases
- Diabetes Mellitus
- Female
- Gene Expression Regulation
- Gene Regulatory Networks
- Genetic Predisposition to Disease
- Granulosa Cells
- Humans
- Inflammation
- Insulin Resistance
- Polycystic Ovary Syndrome
- Transcriptome