Article
The emergence of antibiotic resistance: myths and facts in clinical practice.
Intensive care medicine - 1 Jan 1990
Hamilton-Miller J M
Abstract excerpt
Selection pressure, caused by the use of antibiotics--especially in hospitals--is the main factor responsible for the emergence of antibiotic-resistant bacteria. Resistance can arise endogenously by mutation (one-step, as found for Mycobacterium tuberculosis to rifampicin, or multi-step, as in go...
Topics
- Anti-Bacterial Agents
- Cell Membrane Permeability
- Clinical Protocols
- Drug Resistance, Microbial
- Humans
- Mutation
- Organ Specificity
- Practice Patterns, Physicians'