Article
Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression.
Molecular psychiatry - 1 Jul 2009
Lintas C, Sacco R, Garbett K, Mirnics K, Militerni R, Bravaccio C, Curatolo P, Manzi B, Schneider C, Melmed R, Elia M, Pascucci T, Puglisi-Allegra S, Reichelt K-L, Persico A M
Abstract excerpt
Protein kinase C enzymes play an important role in signal transduction, regulation of gene expression and control of cell division and differentiation. The fsI and betaII isoenzymes result from the alternative splicing of the PKCbeta gene (PRKCB1), previously found to be associated with autism. W...
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