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Article

Redox instability and hemin loss of mutant sperm whale myoglobins induced by 4-hydroxynonenal in vitro.

Journal of agricultural and food chemistry - 29 Aug 2012

Tatiyaborworntham Nantawat, Faustman Cameron, Yin Shuang, Ramanathan Ranjith, Mancini Richard A, Suman Surendranath P, Beach Carol M, Maheswarappa Naveena B, Grunwald Eric W, Richards Mark P

Abstract excerpt

The effects of 4-hydroxy-2-nonenal (HNE) on redox stability of Oxy- and Deoxy- wild-type (WT) and recombinant sperm whale myoglobins (P88H/Q152H, L29F, H97A, and H64F) and hemin loss from Met-myoglobin (Mb) were investigated. HNE induced greater redox instability in WT and mutant Mbs compared to controls (p < 0.05). The extent of HNE-induced OxyMb oxidation was lesser in L29F (p < 0.05) and greater in H97A and...

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PMID: 22873347
DOI: 10.1021/jf301770p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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