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Article

Structural basis for the recognition of Lewis antigens by genogroup I norovirus.

Journal of virology - 1 Oct 2012

Kubota Tomomi, Kumagai Akiko, Ito Hiromi, Furukawa Sanae, Someya Yuichi, Takeda Naokazu, Ishii Koji, Wakita Takaji, Narimatsu Hisashi, Shirato Haruko

Abstract excerpt

Noroviruses (NoVs) bind to histo-blood group antigens, namely, ABH antigens and Lewis antigens. We previously showed the NoVs GI/2, GI/3, GI/4, and GI/8 were able to strongly bind to Lewis a (Le(a)) antigen, which is expressed by individuals who are nonsecretors. In this study, to investigate how Lewis antigens interact with GI NoV virion protein 1 (VP1), we determined the crystal structures of the P domain of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22855491
DOI: 10.1128/JVI.00278-12
PMCID: PMC3457155

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