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Genetic variation of CTNNB1 gene is associated with susceptibility and prognosis of gastric cancer in a Chinese population.

Mutagenesis - 1 Nov 2012

Wang Shizhi, Tian Yuanyuan, Wu Dongmei, Zhu Haixia, Luo Dewei, Gong Weida, Zhou Yan, Zhou Jianwei, Zhang Zhengdong

Abstract excerpt

Gastric cancer is the second leading cause of cancer-related death worldwide with a low 5-year survival (S5y) after initial diagnosis. Although aberrant Wnt/β-catenin (CTNNB1) signaling has been observed in multiple human cancers, there is no information on the role of CTNNB1 polymorphisms in gastric cancer risk and S5y. We performed a genetic association study to analyse the correlation between the five tagged...

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PMID: 22848100
DOI: 10.1093/mutage/ges027

Genes

CTNNB1

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