Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users.

doi:10.1016/j.biopsych.2012.06.020

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Article

Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users.

Biological psychiatry - 15 Nov 2012

Di Forti Marta, Iyegbe Conrad, Sallis Hannah, Kolliakou Anna, Falcone M Aurora, Paparelli Alessandra, Sirianni Miriam, La Cascia Caterina, Stilo Simona A, Marques Tiago Reis, Handley Rowena, Mondelli Valeria, Dazzan Paola, Pariante Carmine, David Anthony S, Morgan Craig, Powell John, Murray Robin M

Abstract excerpt

BACKGROUND: Cannabis use is associated with an increased risk of psychosis. One study has suggested that genetic variation in the AKT1 gene might influence this effect. METHODS: In a case-control study of 489 first-episode psychosis patients and 278 control subjects, we investigated the interaction between variation at the AKT1 rs2494732 single nucleotide polymorphism and cannabis use in increasing the risk of...

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PMID: 22831980
DOI: 10.1016/j.biopsych.2012.06.020

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AKT1

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