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Article

Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance

9 Jul 2012

Abstract excerpt

Resistance to the HER2-targeted antibody trastuzumab is a major clinical concern in the treatment of HER2-overexpressing metastatic breast cancer. Increased expression or signaling of the insulin-like growth factor-I receptor (IGF-IR) has been reported in a subset of cell lines and clinical samples derived from trastuzumab-resistant breast cancers. Genetic and pharmacologic inhibition of IGF-IR signaling has been...

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PMID: 22830017
DOI: 10.1155/2012/648965

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