Article
The fallacy of ratio correction to address confounding factors.
Laboratory animals - 1 Jul 2012
Karp Natasha A, Segonds-Pichon Anne, Gerdin Anna-Karin B, Ramírez-Solis Ramiro, White Jacqueline K
Abstract excerpt
Scientists aspire to measure cause and effect. Unfortunately confounding variables, ones that are associated with both the probable cause and the outcome, can lead to an association that is true but potentially misleading. For example, altered body weight is often observed in a gene knockout; however, many other variables, such as lean mass, will also change as the body weight changes. This leaves the researcher...
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