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Developmental and Epigenetic Anomalies in Cloned Cattle

25 Jul 2012

Abstract excerpt

Many of the developmental anomalies observed in cloned animals are related to foetal and placental overgrowth, a phenomenon known as the 'large offspring syndrome' (LOS) in ruminants. It has been hypothesized that the epigenetic control of imprinted genes, that is, genes that are expressed in a parental-specific manner, is at the root of LOS. Our recent research has focused on understanding epigenetic alterations...

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PMID: 22827358
DOI: 10.1111/j.1439-0531.2012.02063.x

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