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Article

Clinical and genetic analysis of four Taiwanese families with autosomal dominant hereditary spastic paraplegia.

Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Jul 2012

Lan Min-Yu, Fu Ser-Chen, Chang Yung-Yee, Wu-Chou Yah-Huei, Lai Szu-Chia, Chen Rou-Shyan, Lu Chin-Song

Abstract excerpt

BACKGROUND/PURPOSE: Hereditary spastic paraplegias (HSPs) are clinically and genetically heterogeneous neurodegenerative disorders. Defects in the SPG4 and SPG3A genes are the two leading causes of HSPs with autosomal dominant inheritance (AD-HSPs). The purpose of this study was to investigate the clinical features and associated genetic mutations in Taiwanese families with AD-HSP. METHODS: Four kindreds with...

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Source

Identifiers

PMID: 22817815
DOI: 10.1016/j.jfma.2011.06.016

Genes

SPAST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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