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Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells

20 Jul 2012

Abstract excerpt

INTRODUCTION: To date, no single most-appropriate factor or delivery method has been identified for the purpose of mesenchymal stem cell (MSC)-based treatment of cartilage injury. Therefore, in this study we tested whether gene delivery of the growth factor Indian hedgehog (IHH) was able to induce chondrogenesis in human primary MSCs, and whether it was possible by such an approach to modulate the appearance of...

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PMID: 22817660
DOI: 10.1186/ar3921

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